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Antibody Product Overview
| ELK.No | ES5806 |
| Product name | SR-6 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | HTR6; 5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 3362 |
| Human Swiss-Prot | P50406 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SR-6 |
| Fields | >>Calcium signaling pathway;>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Serotonergic synapse |
| Gene name | HTR6 |
| Protein name | 5-hydroxytryptamine receptor 6 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 15565 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9R1C8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 64354 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P31388 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human 5-HT-6. AA range:221-270 |
| Specificity | SR-6 Polyclonal Antibody detects endogenous levels of SR-6 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 47kD |
| Background | This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013], |
| Function | function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in several human brain regions, most prominently in the caudate nucleus., |
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
| Expression | Expressed in several human brain regions, most prominently in the caudate nucleus. |
Additional Images
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Western Blot analysis of A549 cells using SR-6 Polyclonal Antibody
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: AO-06-ES5806-100
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