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Antibody Product Overview
| ELK.No | ES5807 |
| Product name | SR-7 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | IF;ELISA |
| Other name | HTR7; 5-hydroxytryptamine receptor 7; 5-HT-7; 5-HT7; 5-HT-X; Serotonin receptor 7 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 3363 |
| Human Swiss-Prot | P34969 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SR-7 |
| Fields | >>Ras signaling pathway;>>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Serotonergic synapse |
| Gene name | HTR7 |
| Protein name | 5-hydroxytryptamine receptor 7 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 15566 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P32304 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 65032 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P32305 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HTR7. AA range:391-440 |
| Specificity | SR-7 Polyclonal Antibody detects endogenous levels of SR-7 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 54kD |
| Observed band (KD) | |
| Background | The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008], |
| Function | alternative products:Isoform A and isoform B appear to be expressed at higher levels,function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels, and isoform D is a minor isoform., |
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
| Expression | Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in terms of expression. |
Additional Images
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Immunofluorescence analysis of COS7 cells, using HTR7 Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES5807-50
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