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Antibody Product Overview
| ELK.No | ES6237 |
| Product name | Manic Fringe rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | MFNG; Beta-1; 3-N-acetylglucosaminyltransferase manic fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 4242 |
| Human Swiss-Prot | O00587 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Manic Fringe |
| Fields | >>Other types of O-glycan biosynthesis;>>Notch signaling pathway;>>Human papillomavirus infection |
| Gene name | MFNG |
| Protein name | Beta-1,3-N-acetylglucosaminyltransferase manic fringe |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 17305 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O09008 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MFNG. AA range:61-110 |
| Specificity | Manic Fringe Polyclonal Antibody detects endogenous levels of Manic Fringe protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 38kD |
| Background | This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq, Oct 2009], |
| Function | catalytic activity:Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.,function:Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity.,online information:Beta-1,3-N-acetylglucosaminyltransferase manic fringe,online information:GlycoGene database,similarity:Belongs to the glycosyltransferase 31 family., |
| Subcellular location | Golgi apparatus membrane ; Single-pass type II membrane protein . |
| Expression | Lymph, |
Additional Images
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Western blot analysis of the lysates from HepG2 cells using MFNG antibody.
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: AO-06-ES6237-100
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