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Antibody Product Overview
| ELK.No | ES6525 |
| Product name | RNF138 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC |
| Other name | RNF138; NARF; HSD-4; HSD4; E3 ubiquitin-protein ligase RNF138; Nemo-like kinase-associated RING finger protein; NLK-associated RING finger protein; hNARF; RING finger protein 138 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 51444 |
| Human Swiss-Prot | Q8WVD3 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RNF138 |
| Fields | |
| Gene name | RNF138 |
| Protein name | E3 ubiquitin-protein ligase RNF138 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 56515 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9CQE0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 94196 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q99PD2 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RNF138. AA range:31-80 |
| Specificity | RNF138 Polyclonal Antibody detects endogenous levels of RNF138 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 28kD |
| Background | ring finger protein 138(RNF138) Homo sapiens The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008], |
| Function | domain:The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.,function:E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.,pathway:Protein modification; protein ubiquitination.,PTM:Auto-ubiquitinated.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RING-type zinc finger.,subunit:Interacts with nlk., |
| Subcellular location | Chromosome . Recruited at DNA damage sites (PubMed:26502055). Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers (PubMed:26502055, PubMed:26502057). . |
| Expression | Placenta,Testis,Uterus, |
Additional Images
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Western blot analysis of lysates from MCF-7 cells, using RNF138 Antibody. The lane on the right is blocked with the synthesized peptide.
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Immunohistochemical analysis of paraffin-embedded human oophoroma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES6525-50
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