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Antibody Product Overview
| ELK.No | ES6648 |
| Product name | GPR85 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | IHC;IF;ELISA |
| Other name | GPR85; SREB2; Probable G-protein coupled receptor 85; Super conserved receptor expressed in brain 2 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 54329 |
| Human Swiss-Prot | P60893 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GPR85 |
| Fields | |
| Gene name | GPR85 |
| Protein name | Probable G-protein coupled receptor 85 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 64450 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P60894 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 64020 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P60895 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GPR85. AA range:181-230 |
| Specificity | GPR85 Polyclonal Antibody detects endogenous levels of GPR85 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 42kD |
| Observed band (KD) | |
| Background | Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM, Aug 2008], |
| Function | function:Orphan receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Highly expressed in brain and testis. Lower levels in small intestine, placenta and spleen. In brain regions, detected in all regions tested, but somewhat lower levels in the corpus callosum, medulla and spinal cord., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum . |
| Expression | Highly expressed in brain and testis. Lower levels in small intestine, placenta and spleen. In brain regions, detected in all regions tested, but somewhat lower levels in the corpus callosum, medulla and spinal cord. |
Additional Images
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Immunofluorescence analysis of LOVO cells, using GPR85 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using GPR85 Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES6648-50
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