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Antibody Product Overview
| ELK.No | ES6652 |
| Product name | SNAT2 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA;IHC |
| Other name | SLC38A2; ATA2; KIAA1382; SAT2; SNAT2; Sodium-coupled neutral amino acid transporter 2; Amino acid transporter A2; Protein 40-9-1; Solute carrier family 38 member 2; System A amino acid transporter 2; System A transporter 1; System N amino a |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 54407 |
| Human Swiss-Prot | Q96QD8 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SNAT2 |
| Fields | >>Glutamatergic synapse;>>GABAergic synapse;>>Protein digestion and absorption |
| Gene name | SLC38A2 |
| Protein name | Sodium-coupled neutral amino acid transporter 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q8CFE6 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SLC38A2. AA range:151-200 |
| Specificity | SNAT2 Polyclonal Antibody detects endogenous levels of SNAT2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 50kD |
| Background | enzyme regulation:Inhibited by N-methyl-D-glucamine and probably choline.,function:Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.,induction:Up-regulated upon hypertonic conditions and amino acid deprivation.,miscellaneous:Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress.,PTM:Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.,similarity:Belongs to the amino acid/polyamine transporter 2 family.,subcellular location:Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.,tissue specificity:Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level)., |
| Function | enzyme regulation:Inhibited by N-methyl-D-glucamine and probably choline.,function:Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.,induction:Up-regulated upon hypertonic conditions and amino acid deprivation.,miscellaneous:Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress.,PTM:Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.,similarity:Belongs to the amino acid/polyamine transporter 2 family.,subcellular location:Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similar |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. . |
| Expression | Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level). |
Additional Images
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Western blot analysis of lysates from HeLa cells, using SLC38A2 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from HeLa cells using SLC38A2 antibody.
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Immunohistochemical analysis of paraffin-embedded human Colon cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES6652-50
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