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Antibody Product Overview
| ELK.No | ES6874 |
| Product name | Connexin 47 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IF;ELISA |
| Other name | GJC2; GJA12; Gap junction gamma-2 protein; Connexin-46.6; Cx46.6; Connexin-47; Cx47; Gap junction alpha-12 protein |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 57165 |
| Human Swiss-Prot | Q5T442 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Connexin 47 |
| Fields | |
| Gene name | GJC2 |
| Protein name | Gap junction gamma-2 protein |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q8BQU6 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CXG2. AA range:21-70 |
| Specificity | Connexin 47 Polyclonal Antibody detects endogenous levels of Connexin 47 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 47kD |
| Background | This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1. [provided by RefSeq, Jul 2008], |
| Function | caution:It is uncertain whether Met-1 or Met-4 is the initiator.,disease:Defects in GJC2 are the cause of Leukodystrophy hypomyelinating type 2 (HLD2) [MIM:608804]; also known as Pelizaeus-Merzbacher-like disease autosomal recessive type 1. HLD2 is an autosomal recessive hypomyelinating leukodystrophy characterized by nystagmus, impaired motor development, ataxia, choreoathetotic movements, dysarthria and progressive spasticity.,function:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems.,similarity:Belongs to the connexin family. Gamma-type subfamily.,subunit:A connexon is composed of a hexamer of connexins. Interacts with TJP1.,tissue specificity:Expressed in central nervous system, |
| Subcellular location | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. |
| Expression | Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles. |
Additional Images
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Western Blot analysis of A549 cells using Connexin 47 Polyclonal Antibody
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Immunofluorescence analysis of A549 cells, using CXG2 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from A549 cells, using CXG2 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES6874-50
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