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RGS16 (phospho Tyr168) rabbit pAb
AO-06-ES7044-50
Antibody Product Overview
| ELK.No | ES7044 |
| Product name | RGS16 (phospho Tyr168) rabbit pAb |
| Reactivity | Human;Mouse;Rat;Monkey |
| Applications | WB;ELISA;IHC |
| Other name | RGS16; RGSR; Regulator of G-protein signaling 16; RGS16; A28-RGS14P; Retinal-specific RGS; RGS-r; hRGS-r; Retinally abundant regulator of G-protein signaling |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6004 |
| Human Swiss-Prot | O15492 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RGS16 |
| Fields | |
| Gene name | RGS16 |
| Protein name | Regulator of G-protein signaling 16 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 19734 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P97428 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | P56700 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RGS16 around the phosphorylation site of Tyr168. AA range:141-190 |
| Specificity | Phospho-RGS16 (Y168) Polyclonal Antibody detects endogenous levels of RGS16 protein only when phosphorylated at Y168. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 30kD |
| Background | The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008], |
| Function | function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May play a role in regulating the kinetics of signaling in the phototransduction cascade.,PTM:Palmitoylated on Cys-2 and/or Cys-12.,PTM:Phosphorylation on Tyr-168 upon EGFR stimulation. Enhanced GTPase accelerating (GAP) activity on G(i)-alpha.,similarity:Contains 1 RGS domain.,tissue specificity:Abundantly expressed in retina with lower levels of expression in most other tissues., |
| Subcellular location | Membrane ; Lipid-anchor . |
| Expression | Abundantly expressed in retina with lower levels of expression in most other tissues. |
Additional Images
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Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using RGS16 (Phospho-Tyr168) Antibody
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Western blot analysis of lysates from COS7 cells treated with heat shock, using RGS16 (Phospho-Tyr168) Antibody. The lane on the right is blocked with the phospho peptide.
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Immunohistochemical analysis of paraffin-embedded human Breast cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES7044-50
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