Français
English
Antibody Product Overview
| ELK.No | ES7158 |
| Product name | SRp40 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | IHC;IF;ELISA |
| Other name | SRSF5; HRS; SFRS5; SRP40; Serine/arginine-rich splicing factor 5; Delayed-early protein HRS; Pre-mRNA-splicing factor SRP40; Splicing factor; arginine/serine-rich 5 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6430 |
| Human Swiss-Prot | Q13243 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SRp40 |
| Fields | >>Spliceosome;>>Herpes simplex virus 1 infection |
| Gene name | SRSF5 |
| Protein name | Serine/arginine-rich splicing factor 5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 20384 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O35326 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 29667 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q09167 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SFRS5. AA range:71-120 |
| Specificity | SRp40 Polyclonal Antibody detects endogenous levels of SRp40 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 31kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016], |
| Function | function:Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.,PTM:Extensively phosphorylated on serine residues in the RS domain.,similarity:Belongs to the splicing factor SR family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subunit:Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2., |
| Subcellular location | Nucleus. |
| Expression | Brain,Colon,Epithelium,Fetal brain,Human endometrium carcin |
Additional Images
No image
Immunofluorescence analysis of MCF7 cells, using SFRS5 Antibody. The picture on the right is blocked with the synthesized peptide.
No image
Immunohistochemical analysis of paraffin-embedded human spleen. 1, Tris-EDTA,pH9.0 was used for antigen retrieval. 2 Antibody was diluted at 1:200(4° overnight.3,Secondary antibody was diluted at 1:200(room temperature, 45min).
No image
No image
: AO-06-ES7158-50
: 10 Produits
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package