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Antibody Product Overview
| ELK.No | ES7193 |
| Product name | APC1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | IHC;IF;ELISA |
| Other name | ANAPC1; TSG24; Anaphase-promoting complex subunit 1; APC1; Cyclosome subunit 1; Mitotic checkpoint regulator; Testis-specific gene 24 protein |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 64682 |
| Human Swiss-Prot | Q9H1A4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | APC1 |
| Fields | >>Cell cycle;>>Oocyte meiosis;>>Ubiquitin mediated proteolysis;>>Progesterone-mediated oocyte maturation;>>Human T-cell leukemia virus 1 infection |
| Gene name | ANAPC1 |
| Protein name | Anaphase-promoting complex subunit 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 17222 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P53995 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human APC1. AA range:654-703 |
| Specificity | APC1 Polyclonal Antibody detects endogenous levels of APC1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 217kD |
| Observed band (KD) | |
| Background | This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011], |
| Function | function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.,similarity:Belongs to the APC1 family.,similarity:Contains 4 PC repeats.,subunit:The APC/C is composed of at least 11 subunits., |
| Subcellular location | nucleoplasm,anaphase-promoting complex,cytosol, |
| Expression | Colon,Epithelium,Ovary,Placenta, |
Additional Images
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Immunofluorescence analysis of HepG2 cells, using APC1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using APC1 Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES7193-50
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