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Antibody Product Overview
| ELK.No | ES7329 |
| Product name | TACC1 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;IHC;IF;ELISA |
| Other name | TACC1; KIAA1103; Transforming acidic coiled-coil-containing protein 1; Gastric cancer antigen Ga55; Taxin-1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6867 |
| Human Swiss-Prot | O75410 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TACC1 |
| Fields | |
| Gene name | TACC1 |
| Protein name | Transforming acidic coiled-coil-containing protein 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 320165 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q6Y685 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TACC1. AA range:11-60 |
| Specificity | TACC1 Polyclonal Antibody detects endogenous levels of TACC1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 87kD |
| Background | This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009], |
| Function | alternative products:Additional isoforms seem to exist,developmental stage:Expressed at high level during early embryogenesis.,function:Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.,miscellaneous:Down-regulated in a subset of cases of breast cancer.,PTM:Isoform 1 is heavily phosphorylated; isoform 6 is not. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the TACC family.,similarity:Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains.,subcellular location:Nucleus during interphase. Weakly concentrated at centrosomes during mitosis.,subunit:Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with the Aurora kinases A and B (STK6 and AURKB). Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF.,tissue specificity:Isoform 1, isoform 3 and isoform 5 a |
| Subcellular location | Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody . Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. .; [Isoform 5]: Membrane ; Lipid-anchor .; [Isoform 10]: Cytoplasm . |
| Expression | Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer. |
Additional Images
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Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
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Immunofluorescence analysis of MCF7 cells, using TACC1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from K562 cells, using TACC1 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from HeLa cells using TACC1 antibody.
: AO-06-ES7329-50
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