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Antibody Product Overview
| ELK.No | ES7348 |
| Product name | TBX3 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | TBX3; T-box transcription factor TBX3; T-box protein 3 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6926 |
| Human Swiss-Prot | O15119 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TBX3 |
| Fields | >>Signaling pathways regulating pluripotency of stem cells |
| Gene name | TBX3 |
| Protein name | T-box transcription factor TBX3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 21386 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P70324 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 353305 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q7TST9 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TBX3. AA range:301-350 |
| Specificity | TBX3 Polyclonal Antibody detects endogenous levels of TBX3 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 79kD |
| Background | This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008], |
| Function | disease:Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS) [MIM:181450]. UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands.,function:Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:Widely expressed., |
| Subcellular location | Nucleus . |
| Expression | Widely expressed. |
Additional Images
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Western Blot analysis of KB cells using TBX3 Polyclonal Antibody diluted at 1:1000
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Western blot analysis of mouse-kidney mouse-brain KB 293T lysis using TBX3 antibody. Antibody was diluted at 1:1000
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: AO-06-ES7348-50
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