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Antibody Product Overview
| ELK.No | ES7544 |
| Product name | CA III rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | CA3; Carbonic anhydrase 3; Carbonate dehydratase III; Carbonic anhydrase III; CA-III |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 761 |
| Human Swiss-Prot | P07451 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CA III |
| Fields | >>Nitrogen metabolism;>>Metabolic pathways |
| Gene name | CA3 |
| Protein name | Carbonic anhydrase 3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 12350 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P16015 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 54232 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P14141 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CA3. AA range:141-190 |
| Specificity | CA III Polyclonal Antibody detects endogenous levels of CA III protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 38kD |
| Background | Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008], |
| Function | catalytic activity:H(2)CO(3) = CO(2) + H(2)O.,cofactor:Zinc.,developmental stage:At 6 weeks gestation, transcripts accumulate at low levels in the somites and at high levels throughout the notochord. As gestation continues, CA3 becomes abundant in all developing muscle masses and continues at high to moderate levels in the notochord.,function:Reversible hydration of carbon dioxide.,similarity:Belongs to the alpha-carbonic anhydrase family.,tissue specificity:Muscle specific., |
| Subcellular location | Cytoplasm . |
| Expression | Muscle specific. |
Additional Images
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Western blot analysis of lysates from HUVEC cells, using CA3 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from HUVECcells using CA3 antibody.
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: AO-06-ES7544-100
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