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Antibody Product Overview
| ELK.No | ES7586 |
| Product name | TNF-IP 8L2 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | TNFAIP8L2; Tumor necrosis factor alpha-induced protein 8-like protein 2; TIPE2; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2; Inflammation factor protein 20 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 79626 |
| Human Swiss-Prot | Q6P589 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TNF-IP 8L2 |
| Fields | |
| Gene name | TNFAIP8L2 |
| Protein name | Tumor necrosis factor alpha-induced protein 8-like protein 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 69769 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9D8Y7 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 310663 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q6AYJ8 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TNFAIP8L2. AA range:11-60 |
| Specificity | TNF-IP 8L2 Polyclonal Antibody detects endogenous levels of TNF-IP 8L2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 20kD |
| Background | domain:The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.,function:Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.,similarity:Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.,subunit:May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8., |
| Function | domain:The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.,function:Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.,similarity:Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.,subunit:May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8., |
| Subcellular location | cytoplasm, |
| Expression | Lymph node,Pancreas,Small intestine, |
Additional Images
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Western blot analysis of the lysates from HeLa cells using TNFAIP8L2 antibody.
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: AO-06-ES7586-50
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