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Antibody Product Overview
| ELK.No | ES7799 |
| Product name | REPS1 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA;IHC |
| Other name | REPS1; RalBP1-associated Eps domain-containing protein 1; RalBP1-interacting protein 1 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 85021 |
| Human Swiss-Prot | Q96D71 |
| Source | Rabbit |
| Isotype | IgG |
| Target | REPS1 |
| Fields | |
| Gene name | REPS1 |
| Protein name | RalBP1-associated Eps domain-containing protein 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | O54916 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human REPS1. AA range:597-646 |
| Specificity | REPS1 Polyclonal Antibody detects endogenous levels of REPS1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 80kD |
| Background | This gene encodes a signaling adaptor protein with two EH domains that interacts with proteins that participate in signaling, endocytosis and cytoskeletal changes. The encoded protein has been found in association with intersectin 1 and Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1 when intersectin 1 was isolated from clathrin-coated pits. The encoded protein has also been shown to interact with amphiphysin, a cytoplasmic protein at the surface of synaptic vesicles. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014], |
| Function | function:May coordinate the cellular actions of activated EGF receptors and Ral-GTPases.,PTM:EGF stimulates phosphorylation on Tyr-residues.,similarity:Contains 1 EF-hand domain.,similarity:Contains 1 EH domain.,subunit:Homodimer (Potential). Interacts with RAB11FIP2. Interacts with RALBP1, CRK and GRB2. Binding to RALBP1 does not affect its Ral-binding activity. Forms a complex with the SH3 domains of CRK and GRB2 which may link it to an EGF-responsive tyrosine kinase., |
| Subcellular location | Membrane, clathrin-coated pit . Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits. |
| Expression | Widely expressed with highest levels in heart and testis. |
Additional Images
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Western blot analysis of REPS1 Antibody. The lane on the right is blocked with the REPS1 peptide.
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Western blot analysis of the lysates from K562 cells using REPS1 antibody.
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Immunohistochemical analysis of paraffin-embedded human Colon cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES7799-100
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