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Antibody Product Overview
| ELK.No | ES7800 |
| Product name | MMP-23 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA;IHC |
| Other name | MMP23A; MMP21; MMP23B; MMP21; MMP22; Matrix metalloproteinase-23; MMP-23; Femalysin; MIFR-1; Matrix metalloproteinase-21; MMP-21; Matrix metalloproteinase-22; MMP-22 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8510 |
| Human Swiss-Prot | O75900 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MMP-23 |
| Fields | |
| Gene name | MMP23A |
| Protein name | Matrix metalloproteinase-23 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 26561 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O88676 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 94339 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | O88272 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MMP-23. AA range:341-390 |
| Specificity | MMP-23 Polyclonal Antibody detects endogenous levels of MMP-23 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 44kD |
| Background | This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008], |
| Function | cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Inhibited by TIMP2.,function:Protease.,PTM:N-glycosylated.,PTM:Proteolytic cleavage might yield an active form.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,subcellular location:A secreted form produced by proteolytic cleavage seems also to exist.,tissue specificity:Predominantly expressed in ovary, testis and prostate., |
| Subcellular location | Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Membrane ; Single-pass type II membrane protein . A secreted form produced by proteolytic cleavage may also exist. . |
| Expression | Predominantly expressed in ovary, testis and prostate. |
Additional Images
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Western blot analysis of lysates from SKOV3 cells, using MMP-23 Antibody. The lane on the right is blocked with the synthesized peptide.
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Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES7800-50
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