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Antibody Product Overview
| ELK.No | ES7832 |
| Product name | KLF7 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;IHC |
| Other name | KLF7; UKLF; Krueppel-like factor 7; Ubiquitous krueppel-like factor |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 8609 |
| Human Swiss-Prot | O75840 |
| Source | Rabbit |
| Isotype | IgG |
| Target | KLF7 |
| Fields | |
| Gene name | KLF7 |
| Protein name | Krueppel-like factor 7 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 93691 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q99JB0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human KLF7. AA range:171-220 |
| Specificity | KLF7 Polyclonal Antibody detects endogenous levels of KLF7 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 41kD |
| Background | The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012], |
| Function | domain:The acidic N-terminal part may favor interaction with the basic domain of transcription factors.,function:Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,tissue specificity:Ubiquitous and highly expressed in brain and spinal cord in the adult, and in kidney and brain in the embryo., |
| Subcellular location | Nucleus . |
| Expression | Widely expressed. |
Additional Images
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Western blot analysis of KLF7 Antibody. The lane on the right is blocked with the KLF7 peptide.
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Immunohistochemical analysis of paraffin-embedded human Gastric adenocarcinoma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES7832-100
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