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Antibody Product Overview
| ELK.No | ES7903 |
| Product name | eIF2Bδ rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | EIF2B4; EIF2BD; Translation initiation factor eIF-2B subunit delta; eIF-2B GDP-GTP exchange factor subunit delta |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 8890 |
| Human Swiss-Prot | Q9UI10 |
| Source | Rabbit |
| Isotype | IgG |
| Target | eIF2Bδ |
| Fields | >>Herpes simplex virus 1 infection |
| Gene name | EIF2B4 |
| Protein name | Translation initiation factor eIF-2B subunit delta |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 13667 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q61749 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 117019 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q63186 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human EIF2B4. AA range:226-275 |
| Specificity | eIF2Bδ Polyclonal Antibody detects endogenous levels of eIF2Bδ protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 57kD |
| Background | Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Function | disease:Defects in EIF2B4 are a cause of leukodystrophy with vanishing white matter (VWM) [MIM:603896]. VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called |
| Subcellular location | cytoplasm,cytosol,eukaryotic translation initiation factor 2B complex, |
| Expression | Adrenal gland,Brain,Lung,Testis,Uterus, |
Additional Images
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Western blot analysis of EIF2B4 Antibody. The lane on the right is blocked with the EIF2B4 peptide.
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Western blot analysis of the lysates from HeLa cells using EIF2B4 antibody.
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: AO-06-ES7903-100
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