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Antibody Product Overview
| ELK.No | ES7986 |
| Product name | ACTR-IIA rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | ACVR2A; ACVR2; Activin receptor type-2A; Activin receptor type IIA; ACTR-IIA; ACTRIIA |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 92 |
| Human Swiss-Prot | P27037 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ACTR-IIA |
| Fields | >>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Signaling pathways regulating pluripotency of stem cells;>>Fluid shear stress and atherosclerosis |
| Gene name | ACVR2A |
| Protein name | Activin receptor type-2A |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 11480 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P27038 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 29263 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P38444 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ACTR-IIA. AA range:10-59 |
| Specificity | ACTR-IIA Polyclonal Antibody detects endogenous levels of ACTR-IIA protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 48kD |
| Background | This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013], |
| Function | catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3., |
| Subcellular location | Membrane; Single-pass type I membrane protein. |
| Expression | Mammary gland,Testis, |
Additional Images
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Western blot analysis of lysates from rat kidney, using ACTR-IIA antibody.
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: AO-06-ES7986-100
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