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Antibody Product Overview
| ELK.No | ES8030 |
| Product name | Neurexin I rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC |
| Other name | NRXN1; KIAA0578; Neurexin-1-alpha; Neurexin I-alpha |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9378 |
| Human Swiss-Prot | Q9ULB1 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Neurexin I |
| Fields | |
| Gene name | NRXN1 |
| Protein name | Neurexin-1-alpha |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 18189 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9CS84 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 60391 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q63372 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NRXN1. AA range:502-551 |
| Specificity | Neurexin I Polyclonal Antibody detects endogenous levels of Neurexin I protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 150kD |
| Background | NRXN1 (neurexin 1) encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for NRXN1 in the 3' region. Mutations in NRXN1 are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. |
| Function | cell morphogenesis, cell morphogenesis involved in differentiation, cell motion, cell adhesion, cell-cell signaling,synaptic transmission, axonogenesis, axon guidance, synaptogenesis, transmission of nerve impulse, biological adhesion, cell projection organization, neuron differentiation, neuron projection development, cellular component morphogenesis, cell part morphogenesis, extracellular structure organization, neuron development, cell morphogenesis involved in neuron differentiation, neuron projection morphogenesis, cell projection morphogenesis,synapse organization, neurological system process, |
| Subcellular location | Cell junction, synapse, presynaptic cell membrane ; Single-pass type I membrane protein . |
| Expression | Brain. |
Additional Images
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Western blot analysis of lysates from Jurkat cells, using NRXN1 Antibody. The lane on the right is blocked with the synthesized peptide.
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Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES8030-50
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