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Antibody Product Overview
| ELK.No | ES8040 |
| Product name | HAND1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | IF;ELISA |
| Other name | HAND1; BHLHA27; EHAND; Heart- and neural crest derivatives-expressed protein 1; Class A basic helix-loop-helix protein 27; bHLHa27; Extraembryonic tissues; heart, autonomic nervous system and neural crest derivatives-expressed protein 1; eH |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9421 |
| Human Swiss-Prot | O96004 |
| Source | Rabbit |
| Isotype | IgG |
| Target | HAND1 |
| Fields | >>Signaling pathways regulating pluripotency of stem cells |
| Gene name | HAND1 |
| Protein name | Heart- and neural crest derivatives-expressed protein 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 15110 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q64279 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 59112 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P97832 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HAND1. AA range:141-190 |
| Specificity | HAND1 Polyclonal Antibody detects endogenous levels of HAND1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 24kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008], |
| Function | function:Plays an essential role in early trophoblast differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box).,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND2 and HEY1, HEY2 and HEYL (hairy-related transcription factors).,tissue specificity:Heart., |
| Subcellular location | Nucleus, nucleoplasm . Nucleus, nucleolus . Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity). . |
| Expression | Heart. |
Additional Images
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Immunofluorescence analysis of A549 cells, using HAND1 Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES8040-50
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