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Antibody Product Overview
| ELK.No | ES8098 |
| Product name | RASSF2 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC |
| Other name | RASSF2; KIAA0168; Ras association domain-containing protein 2 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9770 |
| Human Swiss-Prot | P50749 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RASSF2 |
| Fields | >>Hippo signaling pathway - multiple species |
| Gene name | RASSF2 |
| Protein name | Ras association domain-containing protein 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 215653 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8BMS9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 311437 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q3B7D5 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RASSF2. AA range:109-158 |
| Specificity | RASSF2 Polyclonal Antibody detects endogenous levels of RASSF2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 36kD |
| Background | This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008], |
| Function | function:Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SARAH domain.,subunit:Interacts directly with activated KRAS in a GTP-dependent manner.,tissue specificity:Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines., |
| Subcellular location | Nucleus. Cytoplasm. Chromosome, centromere, kinetochore . Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1. |
| Expression | Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines. |
Additional Images
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Western blot analysis of lysates from Jurkat cells, using RASSF2 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from HepG2 cells using RASSF2 antibody.
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Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES8098-50
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