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Antibody Product Overview
| ELK.No | ES8358 |
| Product name | NHERF-2 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | SLC9A3R2; NHERF2; Na(+)/H(+) exchange regulatory cofactor NHE-RF2; NHERF-2; NHE3 kinase A regulatory protein E3KARP; SRY-interacting protein 1; SIP-1; Sodium-hydrogen exchanger regulatory factor 2; Solute carrier family 9 isoform A3 regulatory factor 2; Tyrosine kinase activator protein 1; TKA-1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9351 |
| Human Swiss-Prot | Q15599 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NHERF-2 |
| Fields | >>Aldosterone-regulated sodium reabsorption |
| Gene name | SLC9A3R2 |
| Protein name | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 65962 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9JHL1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 116501 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q920G2 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from NHERF-2 . at AA range: 20-100 |
| Specificity | NHERF-2 Polyclonal Antibody detects endogenous levels of NHERF-2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 37kD |
| Background | This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011], |
| Function | function:Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus.,similarity:Contains 2 PDZ (DHR) domains.,subcellular location:Nuclear, in a punctate pattern.,subunit:Homodimer, and heterodimer with SLC9A3R1. Binds PODXL and PDZK1 (By similarity). Binds ADRB2, SLC9A3, P2RY1, P2YR2, SRY, RDX and LPAR2.,tissue specificity:Widely expressed., |
| Subcellular location | Endomembrane system ; Peripheral membrane protein . Nucleus . Apical cell membrane . Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes (By similarity). Nuclear, in a punctate pattern. . |
| Expression | Widely expressed. |
Additional Images
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Western blot analysis of JK K562 using NHERF-2 antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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: AO-06-ES8358-50
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