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Antibody Product Overview
| ELK.No | ES8419 |
| Product name | ASAH3L rabbit pAb |
| Reactivity | Human;Mouse;Monkey |
| Applications | WB;IHC;IF;ELISA |
| Other name | ACER2; ASAH3L; PP11646; Alkaline ceramidase 2; AlkCDase 2; Alkaline CDase 2; haCER2; Acylsphingosine deacylase 3-like; N-acylsphingosine amidohydrolase 3-like |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 340485 |
| Human Swiss-Prot | Q5QJU3 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ASAH3L |
| Fields | >>Sphingolipid metabolism;>>Metabolic pathways;>>Sphingolipid signaling pathway |
| Gene name | ACER2 |
| Protein name | Alkaline ceramidase 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 230379 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8VD53 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from ASAH3L . at AA range: 50-130 |
| Specificity | ASAH3L Polyclonal Antibody detects endogenous levels of ASAH3L protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 33kD |
| Background | The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010], |
| Function | catalytic activity:N-acylsphingosine + H(2)O = a carboxylate + sphingosine.,function:Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.,similarity:Belongs to the alkaline ceramidase family., |
| Subcellular location | Golgi apparatus membrane ; Multi-pass membrane protein . |
| Expression | Highly expressed in placenta. |
Additional Images
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Western blot analysis of COS7 using ASAH3L antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-breast-cancer, antibody was diluted at 1:200
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Immunohistochemical analysis of paraffin-embedded human-breast-cancer, antibody was diluted at 1:200
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Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
: AO-06-ES8419-50
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