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Antibody Product Overview
| ELK.No | ES8475 |
| Product name | RHEB rabbit pAb |
| Reactivity | Human;Mouse;Rat;Predicted:Cow |
| Applications | WB;ELISA;IHC |
| Other name | Ras homolog enriched in brain |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6009 |
| Human Swiss-Prot | Q15382 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RHEB |
| Fields | >>Phospholipase D signaling pathway;>>Autophagy - animal;>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Cellular senescence;>>Thermogenesis;>>Insulin signaling pathway;>>Thyroid hormone signaling pathway;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Herpes simplex virus 1 infection;>>Choline metabolism in cancer |
| Gene name | RHEB RHEB2 |
| Protein name | RHEB |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 19744 |
| Mouse gene link | |
| Mouse Swiss-Prot | Q921J2 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q62639 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthetic Peptide of RHEB |
| Specificity | This antibody detects endogenous levels of RHEB Polyclonal Antibody at Human;Mouse;Rat;Predicted:Cow, It doesn't reacte with total protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 20kD |
| Background | This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008], |
| Function | function:Not known; binds GTP and exhibits intrinsic GTPase activity.,similarity:Belongs to the small GTPase superfamily. Rheb family.,tissue specificity:Ubiquitous. Highest levels observed in skeletal and cardiac muscle., |
| Subcellular location | Endomembrane system ; Lipid-anchor ; Cytoplasmic side . Golgi apparatus membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, cytosol . Endoplasmic reticulum membrane ; Lipid-anchor ; Cytoplasmic side . |
| Expression | Ubiquitous. Highest levels observed in skeletal and cardiac muscle. |
Additional Images
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Western Blot analysis of mouse-kidney mouse-brain cells using RHEB Polyclonal Antibody diluted at 1:2000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES8475-50
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