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Nanos Homologue 1 (NANOS1) rabbit pAb
AO-06-ES8506-100
Antibody Product Overview
| ELK.No | ES8506 |
| Product name | Nanos Homologue 1 (NANOS1) rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA;IHC |
| Other name | Nanos homolog 1 (NOS-1) (EC_Rep1a) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 340719 |
| Human Swiss-Prot | Q8WY41 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Nanos Homologue 1 (NANOS1) |
| Fields | |
| Gene name | NANOS1 |
| Protein name | Nanos Homologue 1 (NANOS1) |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 332397 |
| Mouse gene link | |
| Mouse Swiss-Prot | Q80WY3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from Nanos Homologue 1 (NANOS1) at AA range: 151-200 |
| Specificity | Nanos Homologue 1 (NANOS1) Polyclonal Antibody detects endogenous levels of Nanos Homologue 1 (NANOS1) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 30kD |
| Background | This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015], |
| Function | domain:The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.,function:May regulate translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets.,similarity:Belongs to the nanos family.,similarity:Contains 1 nanos-type zinc finger.,subunit:Interacts with PUM2.,tissue specificity:Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells., |
| Subcellular location | Cytoplasm, perinuclear region . Cytoplasm . Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells. . |
| Expression | Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness. |
Additional Images
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Western Blot analysis of 3T3 cells using Nanos Homologue 1 (NANOS1) Polyclonal Antibody diluted at 1:1500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Western Blot analysis of various cells using Antibody diluted at 1:1000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-breast-cancer, antibody was diluted at 1:200
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Immunohistochemical analysis of paraffin-embedded human-breast-cancer, antibody was diluted at 1:200
: AO-06-ES8506-100
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