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Antibody Product Overview
| ELK.No | ES8516 |
| Product name | TyrRS rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;ELISA |
| Other name | Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8565 |
| Human Swiss-Prot | P54577 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TyrRS |
| Fields | >>Aminoacyl-tRNA biosynthesis |
| Gene name | YARS |
| Protein name | TyrRS |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 107271 |
| Mouse gene link | |
| Mouse Swiss-Prot | Q91WQ3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q4KM49 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human YARS. AA range:451-500 |
| Specificity | TyrRS Polyclonal Antibody detects endogenous levels of TyrRS |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000,IHC 1:50-300 ELISA 1:10000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).,disease:Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC) [MIM:608323]. CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.,function:Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).,similarity:Belongs to the class-I aminoacyl-tRNA synthetase family.,similarity:Contains 1 tRNA-binding domain.,subunit:Homodimer., |
| Subcellular location | Cytoplasm . |
| Expression | B-cell lymphoma,Bone,Lung,Platelet, |
Additional Images
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Western Blot analysis of Hela cells using TyrRS Polyclonal Antibody diluted at 1:500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200
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Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200
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Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200
: AO-06-ES8516-50
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