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Plasminogen receptor rabbit pAb
AO-06-ES8519-50
Antibody Product Overview
| ELK.No | ES8519 |
| Product name | Plasminogen receptor rabbit pAb |
| Reactivity | Human;Rat |
| Applications | WB;IHC |
| Other name | Plasminogen receptor (KT) (Plg-R(KT)) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 55848 |
| Human Swiss-Prot | Q9HBL7 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Plasminogen receptor |
| Fields | |
| Gene name | PLGRKT |
| Protein name | Plasminogen receptor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 67759 |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9D3P8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | D4ACN8 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human PLGRKT. AA range:1-50 |
| Specificity | Plasminogen receptor Polyclonal Antibody detects endogenous levels of Plasminogen receptor |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 17kD |
| Background | Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. |
| Function | |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/PLAUR. . |
| Expression | Expressed in peripheral blood cells and monocytes. Expressed in adrenal medulla. |
Additional Images
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Western Blot analysis of HEPG2 cells using Plasminogen receptor Polyclonal Antibody diluted at 1:500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human Colon cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES8519-50
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