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Antibody Product Overview
| ELK.No | ES8520 |
| Product name | NLRX1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | NLR family member X1 (Caterpiller protein 11.3;CLR11.3;Nucleotide-binding oligomerization domain protein 26;Nucleotide-binding oligomerization domain protein 5;Nucleotide-binding oligomerization domain protein 9) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 79671 |
| Human Swiss-Prot | Q86UT6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NLRX1 |
| Fields | >>NOD-like receptor signaling pathway;>>RIG-I-like receptor signaling pathway;>>Influenza A |
| Gene name | NLRX1 |
| Protein name | NLRX1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 270151 |
| Mouse gene link | |
| Mouse Swiss-Prot | Q3TL44 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q5FVQ8 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human NLRX1. AA range:581-630 |
| Specificity | NLRX1 Polyclonal Antibody detects endogenous levels of NLRX1 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000, IHC-p 1:50-300, ELISA 1:10000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 108kD |
| Background | The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013], |
| Function | function:Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).,sequence caution:Translated as Trp.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the NLRP family.,similarity:Contains 1 NACHT domain.,similarity:Contains 4 LRR (leucine-rich) repeats.,subunit:Interacts with MAVS.,tissue specificity:Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HELA, 293T, THP-1, HL60, RAJI, and JURKAT cell lines (at protein level)., |
| Subcellular location | Mitochondrion outer membrane . |
| Expression | Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level). |
Additional Images
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Western Blot analysis of HEPG2 Hela cells using NLRX1 Polyclonal Antibody diluted at 1:1000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200
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Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200
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Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
: AO-06-ES8520-100
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