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Antibody Product Overview
| ELK.No | ES8530 |
| Product name | Ini1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | SMARCB1 BAF47 INI1 SNF5L1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6598 |
| Human Swiss-Prot | Q12824 |
| Source | Rabbit |
| Isotype | IgG |
| Target | INI-1 |
| Fields | >>Viral life cycle - HIV-1;>>Thermogenesis;>>Hepatocellular carcinoma |
| Gene name | SMARCB1 BAF47 INI1 SNF5L1 |
| Protein name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 20587 |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9Z0H3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthetic peptide from human protein at AA range: 331-380 |
| Specificity | The antibody detects endogenous Ini1 protein |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 45kD |
| Background | The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015], |
| Function | disease:Defects in SMARCB1 are a cause of rhabdoid tumor (RDT) [MIM:609322]; also called malignant rhabdoid tumor (MRT). Tumor suppressor. Inactivated in rhabdoid tumors. Rhabdoid tumors are a highly malignant group of neoplasms that usually occur in early childhood. SMARCB1/INI1 is also frequently inactivated in epithelioid sarcomas.,disease:Defects in SMARCB1 are a cause of schwannomatosis [MIM:162091]; also called congenital cutaneous neurilemmomatosis. Schwannomas are benign tumors of the peripheral nerve sheath that usually occur singly in otherwise normal individuals. Multiple schwannomas in the same individual suggest an underlying tumor-predisposition syndrome. The most common such syndrome is NF2. The hallmark of NF2 is the development of bilateral vestibular-nerve schwannomas; but two-thirds or more of all NF2-affected individuals develop schwannomas in other locations, and der |
| Subcellular location | Nucleus. |
| Expression | Bra |
Additional Images
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Western Blot analysis of HEPG2 cells using Antibody diluted at 800. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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: AO-06-ES8530-50
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