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Antibody Product Overview
| ELK.No | ES8542 |
| Product name | COL25A1 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | COL25A1 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 84570 |
| Human Swiss-Prot | Q9BXS0 |
| Source | Rabbit |
| Isotype | IgG |
| Target | COL25A1 |
| Fields | >>Protein digestion and absorption |
| Gene name | COL25A1 |
| Protein name | collagen, type XXV, alpha 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 77018 |
| Mouse gene link | |
| Mouse Swiss-Prot | Q99MQ5 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthetic peptide from human protein at AA range: 101-150 |
| Specificity | The antibody detects endogenous COL25A1 protein |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 64kD |
| Background | This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011], |
| Function | caution:The pyrrolidone carboxylic acid reported in PubMed:11927537 probably formed artifactually from Glu-113 during the extraction procedure in 70% formic acid. In PubMed:15522881, the protein was found to have unblocked Glu at the N-terminus.,function:Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.,PTM:Glycosylated.,PTM:Hydroxylated on 11% of proline residues and 49% of lysine residues.,PTM:Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component.,similarity:Contains 7 collagen-like domains.,subcellular location:After proteolytic cleavage, CLAC is secreted.,subunit:Forms homodimers and homotrimers. Binds to the fibrillized forms of beta amyloid peptide 40 (beta-APP40) and beta amyloid peptide 42 (b |
| Subcellular location | Membrane ; Single-pass type II membrane protein . After proteolytic cleavage, CLAC is secreted. |
| Expression | Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease. |
Additional Images
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Western Blot analysis of HEPG2 cells using Antibody diluted at 500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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: AO-06-ES8542-100
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