Français
English
Antibody Product Overview
| ELK.No | ES8634 |
| Product name | PF-4 rabbit pAb |
| Reactivity | Human;Rat |
| Applications | WB;ELISA;IHC |
| Other name | Platelet factor 4 (PF-4;C-X-C motif chemokine 4;Iroplact;Oncostatin-A) [Cleaved into: Platelet factor 4, short form] |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 5196 |
| Human Swiss-Prot | P02776 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PF-4 |
| Fields | >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway |
| Gene name | PF4 CXCL4 SCYB4 |
| Protein name | Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form] |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 56744 |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9Z126 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | P06765 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthetic peptide from human protein at AA range: 51-100 |
| Specificity | The antibody detects endogenous PF-4 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | |
| Background | This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014], |
| Function | function:Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.,mass spectrometry: PubMed:7644496,mass spectrometry:Short form PubMed:7644496,online information:CXCL4 entry,PTM:Binds non-covalently to a proteoglycan molecule.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,subunit:Homotetramer., |
| Subcellular location | Secreted . |
| Expression | Leukocyte, |
Additional Images
No image
Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:200
No image
Western blot analysis of lysates from SW480 cells, primary antibody was diluted at 1:1000, 4°over night
No image
No image
: AO-06-ES8634-50
: 10 Produits
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package