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Antibody Product Overview
| ELK.No | ES8706 |
| Product name | TGFβ2 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | Transforming growth factor beta-2 (TGF-beta-2;BSC-1 cell growth inhibitor;Cetermin;Glioblastoma-derived T-cell suppressor factor;G-TSF;Polyergin) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 7042 |
| Human Swiss-Prot | P61812 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TGFβ2 |
| Fields | >>MAPK signaling pathway;>>Cytokine-cytokine receptor interaction;>>FoxO signaling pathway;>>Cell cycle;>>Cellular senescence;>>TGF-beta signaling pathway;>>Osteoclast differentiation;>>Hippo signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Leishmaniasis;>>Chagas disease;>>Malaria;>>Toxoplasmosis;>>Amoebiasis;>>Tuberculosis;>>Hepatitis B;>>Human T-cell leukemia virus 1 infection;>>Pathways in cancer;>>Proteoglycans in cancer;>>MicroRNAs in cancer;>>Colorectal cancer;>>Renal cell carcinoma;>>Pancreatic cancer;>>Chronic myeloid leukemia;>>Hepatocellular carcinoma;>>Gastric cancer;>>Inflammatory bowel disease;>>Rheumatoid arthritis;>>Hypertrophic cardiomyopathy;>>Dilated cardiomyopathy;>>Diabetic cardiomyopathy |
| Gene name | TGFB2 |
| Protein name | Transforming growth factor beta-2 (TGF-beta-2) (BSC-1 cell growth inhibitor) (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) (Polyergin) |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 21808 |
| Mouse gene link | |
| Mouse Swiss-Prot | P27090 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q07257 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TGF beta2. AA range:361-410 |
| Specificity | The antibody detects endogenous TGFβ2 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 47+12kD |
| Background | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the an |
| Function | disease:A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly [MIM:604229]. Translocation t(1;7)(q41;p21) with HDAC9. Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea.,function:TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.,online information:TGF beta-2 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked., |
| Subcellular location | [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix .; [Transforming growth factor beta-2]: Secreted . |
| Expression | Aorta endothelial cell,Lung, |
Additional Images
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Western blot analysis of mouse-kidney 293T mouse-lung lysate, antibody was diluted at 1000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200
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Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200
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Immunohistochemical analysis of paraffin-embedded human-placenta, antibody was diluted at 1:200
: AO-06-ES8706-50
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