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Antibody Product Overview
| ELK.No | ES8859 |
| Product name | GCM2 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | Chorion-specific transcription factor GCMb (hGCMb) (GCM motif protein 2) (Glial cells missing homolog 2) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9247 |
| Human Swiss-Prot | O75603 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GCM2 |
| Fields | >>Parathyroid hormone synthesis, secretion and action |
| Gene name | GCM2 |
| Protein name | GCM2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 107889 |
| Mouse gene link | |
| Mouse Swiss-Prot | O09102 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human GCM2. at AA range: 21-70 |
| Specificity | GCM2 Polyclonal Antibody detects endogenous levels of GCM2 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 56kD |
| Background | This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism. [provided by RefSeq, Jul 2008], |
| Function | function:Probable transcriptional regulator.,similarity:Contains 1 GCM DNA-binding domain., |
| Subcellular location | Nucleus . |
| Expression | Brain,Fetal brain, |
Additional Images
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Western Blot analysis of 293T cells using primary antibody diluted at 1:500(4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour)
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: AO-06-ES8859-50
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