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Antibody Product Overview
| ELK.No | ES8866 |
| Product name | AFG3L2 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 10939 |
| Human Swiss-Prot | Q9Y4W6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | AFG3L2 |
| Fields | >>Spinocerebellar ataxia |
| Gene name | AFG3L2 |
| Protein name | AFG3L2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 69597 |
| Mouse gene link | |
| Mouse Swiss-Prot | Q8JZQ2 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human AFG3L2. at AA range: 744-793 |
| Specificity | AFG3L2 Polyclonal Antibody detects endogenous levels of AFG3L2 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 88kD |
| Background | This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders. [provided by RefSeq, Jul 2008], |
| Function | cofactor:Binds 1 zinc ion per subunit .,function:Putative ATP-dependent protease.,similarity:In the C-terminal section; belongs to the peptidase M41 family.,similarity:In the N-terminal section; belongs to the AAA ATPase family.,tissue specificity:Ubiquitous., |
| Subcellular location | Mitochondrion . Mitochondrion inner membrane ; Multi-pass membrane protein . |
| Expression | Ubiquitous. Highly expressed in the cerebellar Purkinje cells. |
Additional Images
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Western Blot analysis of 1,mouse-heart 2,293T cells using primary antibody diluted at 1:500(4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour)
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: AO-06-ES8866-100
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