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Antibody Product Overview
| ELK.No | ES8975 |
| Product name | RGS19 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 10287 |
| Human Swiss-Prot | P49795 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RGS19 |
| Fields | |
| Gene name | RGS19 GAIP GNAI3IP |
| Protein name | Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9CX84 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | O70521 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 90-170 |
| Specificity | RGS19 Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 23kD |
| Background | G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008], |
| Function | function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.,PTM:Fatty acylated. Heavily palmitoylated in the cysteine string motif.,PTM:Phosphorylated, mainly on serine residues.,similarity:Contains 1 RGS domain.,subunit:Interacts with GIPC PDZ domain.,tissue specificity:Highest expression in lung. Placenta, liver and heart also express high levels of GAIP., |
| Subcellular location | Membrane; Lipid-anchor. |
| Expression | Highest expression in lung. Placenta, liver and heart also express high levels of GAIP. |
Additional Images
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Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES8975-50
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