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Antibody Product Overview
| ELK.No | ES9964 |
| Product name | OAZ3 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 51686 |
| Human Swiss-Prot | Q9UMX2 |
| Source | Rabbit |
| Isotype | IgG |
| Target | OAZ3 |
| Fields | |
| Gene name | OAZ3 |
| Protein name | Ornithine decarboxylase antizyme 3 (AZ3) (ODC-Az 3) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9R109 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 90-170 |
| Specificity | OAZ3 Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 20kD |
| Background | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that ho |
| Function | alternative products:A ribosomal frameshift occurs between the codons for Ser-28 and Glu-29. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines,developmental stage:Expression starts early in spermiogenesis and finishes in the late spermatid phase.,function:Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration. OAZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells.,miscellaneous:A ribosomal frameshift occurs between the codons for Ser-28 and Glu-29. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.,similarity:Belongs to the ODC antizyme family.,subunit:Interacts with GGN.,tissue specificity:Testis specific., |
| Subcellular location | Nucleus. Cytoplasm . |
| Expression | Testis specific. |
Additional Images
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Western blot analysis of lysates from A431 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES9964-50
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