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Product Information
|
Protein full name |
Disintegrin and metalloproteinase domain-containing protein 15 |
|
Synonyms |
ADAM15, MDC15, ADAM metallopeptidase domain 15 |
|
Uniprot ID |
O88839 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse ADAM15 |
|
Isotype |
IgG |
|
Predicted MW./Observed MW. |
93 kDa / 93 kDa |
|
Purity |
Affinity purification |
Applications
| Applications | Species | Dilution | Positive Tissue |
| WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, lung, heart |
Background
ADAM15 belongs to a family of transmembrane proteins that contain disintegrin and metalloprotease domains. Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation.
Images
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WB analysis of ADAM15(GB11945). Sample: Protein treated by RIPA Lysis Buffer (G2002). Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h. Primary antibody: 1: 500, 4℃ overnight. Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h. |
Storage
| Storage | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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