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Product Information
|
Protein full name |
Lysyl oxidase homolog 2 |
|
Synonyms |
Lysyl oxidase-like protein 2, Loxl2, Lysyl oxidase related protein WS9 14, Lysyl oxidase homolog 2, WS9 14, LOXL2, LOR2, WS9-14, lysyl oxidase like 2, LOR |
|
Uniprot ID |
P58022 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse LOXL2 |
|
Isotype |
IgG |
|
Predicted MW./Observed MW. |
87 kDa / 87 kDa |
|
Purity |
Affinity purification |
|
Subcellular location |
Nucleus, Cytoplasm, Secreted |
Applications
| Applications | Species | Dilution | Positive Tissue |
| WB | Human | 1: 500-1: 1000 | HeLa, Lncap, 293T |
| ICC/IF | Human | 1: 50-1: 200 | HeLa |
Background
LOXL2, also named as WS9-14, belongs to an amine oxidase family whose members have been implicated in crosslink formation in stromal collagens and elastin, cell motility, and tumor development and progression. LOXL2 activity might be a crucial modulator of Snail, providing an additional control mechanism of EMT and tumor progression. Increased LOXL2 expression in colon and esophageal cancer may contribute to tumor progression.
Images
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WB analysis of LOXL2(GB11849). Sample: Protein treated by RIPA Lysis Buffer (G2002). Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h. Primary antibody: 1: 500, 4℃ overnight. Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h. |
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ICC analysis of LOXL2(GB11849)green. Sample: Hela, 4% PFA (G1101) 20min. Blocking buffer: 3% BSA (GC305010) in PBS, RT, 30min. Primary antibody: 1: 50, 4℃ overnight. Secondary antibody: 488 conjugated Goat Anti-Rabbit IgG (H+L) (GB25303), 1: 400, RT, 1h. |
Storage
| Storage | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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