Product Information
Protein full name | Cathepsin K |
Synonyms | Ctsk, Procathepsin K, Cathepsin K, Cathepsin O, Cathepsin X, CTSO |
Uniprot ID | P55097 |
Immunogen | Recombinant protein corresponding to Mouse Cathepsin K |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Cytoplasm |
Applications
| Applications | Species | Dilution | Positive Tissue |
| IHC/IF | Mouse, Rat | 1: 1000-1: 2000 | bone |
Background
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis an autosomal recessive disease characterized by osteosclerosis and short stature.
Images
| IHC analysis of Cathepsin K(GB111276). Sample: Mouse bone, 4% PFA (G1101) 12-24h. Antigen retrieval: Pepsin Antigen Repair Solution,37°C,30min. Primary antibody: 1: 1000, 4°C overnight. Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 200, RT, 1h. |
| IHC analysis of Cathepsin K(GB111276). Sample: Rat bone, 4% PFA (G1101) 12-24h. Antigen retrieval: Pepsin Antigen Repair Solution,37°C,30min. Primary antibody: 1: 1000, 4°C overnight. Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 200, RT, 1h. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.15% ProClin300, 100 µg/mL BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
Datasheet: Download datasheet 1
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