Product Information
Protein full name | Runt-related transcription factor 3 |
Synonyms | AML2, CBF alpha 3, CBFA3, Oncogene AML 2, PEA2 alpha C, PEBP2 alpha C, PEBP2A3, PEBP2aC, RUNX3, Acute myeloid leukemia 2 protein, Core-binding factor subunit alpha-3 |
Uniprot ID | Q64131 |
Immunogen | Recombinant protein corresponding to Mouse RUNX3 |
Isotype | IgG |
Predicted MW./Observed MW. | 44 kDa / 44 kDa |
Purity | Affinity purification |
Applications
| Applications | Species | Dilution | Positive Tissue |
| WB | Mouse, Rat | 1: 500-1: 1000 | liver |
Background
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Images
| WB analysis of RUNX3(GB113627). Sample: Protein treated by RIPA Lysis Buffer (G2002). Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h. Primary antibody: 1: 1000, 4°C overnight. Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.15% ProClin300, 100 µg/mL BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
Datasheet: Download datasheet 1
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