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Antibody Product Overview
| ELK.No | EM1056 |
| Product name | CK16 Mouse mAb |
| Reactivity | Human, Rat, Mouse |
| Applications | IHC |
| Other name | Cytokeratin 16, K16, K1CP, keratin 16, KRT16, KRT16A, NEPPK |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 3868 |
| Human Swiss-Prot | P08779 |
| Source | Mouse |
| Isotype | IgG1 |
| Target | |
| Fields | |
| Gene name | |
| Protein name | |
| Human gene link | |
| Human Swiss link | |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthetic Peptide |
| Specificity | |
| Formulation | |
| Clonality | Monoclonal |
| Dilution | IHC 1:200 |
| Purification | |
| Concentration | 1mg/mL |
| Storage stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Molecular Weight (Da) | |
| Observed band (KD) | 51kDa |
| Background | Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating. |
| Function | |
| Subcellular location | Intermediate filament |
| Expression |
Additional Images
IHC staining of human gullet cancer tissue with CK16 mouse mAb(6F6) diluted at 1:200.
: EM1056-100
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