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Antibody Product Overview
| ELK.No | EM1261 |
| Product name | a-actinin (4A12) Mouse mAb |
| Reactivity | Human, Rat, Mouse |
| Applications | IHC |
| Other name | actinin 1 smooth muscle antibody, actinin alpha 1 antibody, ACTN 1 antibody, FLJ40884 antibody |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 87 |
| Human Swiss-Prot | P12814 |
| Source | Mouse |
| Isotype | IgG1 |
| Target | |
| Fields | |
| Gene name | |
| Protein name | |
| Human gene link | |
| Human Swiss link | |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Recombinant Protein |
| Specificity | |
| Formulation | |
| Clonality | Monoclonal |
| Dilution | IHC 1:100-200 |
| Purification | |
| Concentration | 1mg/mL |
| Storage stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Molecular Weight (Da) | |
| Observed band (KD) | 103kDa |
| Background | α-Actinin belongs to the spectrin family of cytoskeletal proteins. α-Actinin is necessary for the attachment of actin filaments to the Z-lines in skeletal muscle cells, and to the dense bodies in smooth muscle cells. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinated contractions between sarcomeres in the horizontal axis. |
| Function | |
| Subcellular location | Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane |
| Expression |
Additional Images
Immunohistochemical analysis of paraffin-embedded Human Breast Carrcinoma Tissue using a-actinin（EM1261）Mouse mAb diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Human Kidney Tissue using a-actinin（EM1261）Mouse mAb diluted at 1:200.
: EM1261-100
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