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phospho-MLKL (S358) (6B4) Mouse mAb
EM1320-100
Antibody Product Overview
| ELK.No | EM1320 |
| Product name | phospho-MLKL (S358) (6B4) Mouse mAb |
| Reactivity | Human |
| Applications | IHC |
| Other name | Mixed lineage kinase domain like protein, FLJ34389 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 197259 |
| Human Swiss-Prot | Q8NB16 |
| Source | Mouse |
| Isotype | IgG1 |
| Target | |
| Fields | |
| Gene name | |
| Protein name | |
| Human gene link | |
| Human Swiss link | |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthetic Peptide |
| Specificity | |
| Formulation | |
| Clonality | Monoclonal |
| Dilution | IHC 1:100-200 |
| Purification | |
| Concentration | 1mg/mL |
| Storage stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Molecular Weight (Da) | |
| Observed band (KD) | 54kDa |
| Background | Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that was identified as downstream target of RIP3 in the necroptosis pathway. During necroptosis RIP3 is phosphorylated at Ser227, which recruits MLKL and leads to its phosphorylation at Thr357 and Ser358. |
| Function | |
| Subcellular location | Cell membrane, Cytoplasm, Membrane |
| Expression |
Additional Images
Immunohistochemical analysis of paraffin-embedded Human Colon Carcinoma Tissue using Phospho-MLKL S358（EM1320）Mouse mAb diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Human Skin Tissue using Phospho-MLKL S358（EM1320）Mouse mAb diluted at 1:200.
: EM1320-100
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