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Antibody Product Overview
| ELK.No | EM1339 |
| Product name | COX-2 (2G1) Mouse mAb |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Other name | PTGS2 antibody, Prostaglandin H2 synthase 2 antibody, PGHS 2 antibody, Glucocorticoid-regulated inflammatory cyclooxygenase antibody |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 5743 |
| Human Swiss-Prot | P35354 |
| Source | Mouse |
| Isotype | IgG1 |
| Target | |
| Fields | |
| Gene name | |
| Protein name | |
| Human gene link | |
| Human Swiss link | |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthetic Peptide |
| Specificity | |
| Formulation | |
| Clonality | Monoclonal |
| Dilution | IHC 1:100-200 |
| Purification | |
| Concentration | 1mg/mL |
| Storage stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Molecular Weight (Da) | |
| Observed band (KD) | 70kDa |
| Background | Prostaglandin-endoperoxide synthase 2, also known as cyclooxygenase-2 or simply COX-2, is an enzyme that in humans is encoded by the PTGS2 gene. There are two isozymes of COX encoded by distinct gene products: a constitutive COX-1 (this enzyme) and an inducible COX-2, which differ in their regulation of expression and tissue distribution. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. A splice variant of COX-1 termed COX-3 was identified in the CNS of dogs, but does not result in a functional protein in humans. Two smaller COX-1-derived proteins (the partial COX-1 proteins PCOX-1A and PCOX-1B) have also been discovered, but their precise roles are yet to be described. |
| Function | |
| Subcellular location | Endoplasmic reticulum, Membrane, Microsome |
| Expression |
Additional Images
Immunohistochemical analysis of paraffin-embedded Human Colon Carcinoma Tissue using COX-2（EM1339）Mouse mAb diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Human Ovarain Carcinoma Tissue using COX-2（EM1339）Mouse mAb diluted at 1:200.
: EM1339-50
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