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Acetyl NF kB P65（K314/K315) (5G11) Mouse mAb
EM1377-100
Antibody Product Overview
| ELK.No | EM1377 |
| Product name | Acetyl NF kB P65（K314/K315) (5G11) Mouse mAb |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Other name | NF kappa B p65, NFKB3, p65, p65 NF kB, RELA, TF65, Transcription Factor p65 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 5970 |
| Human Swiss-Prot | Q04206 |
| Source | Mouse |
| Isotype | IgG1 |
| Target | |
| Fields | |
| Gene name | |
| Protein name | |
| Human gene link | |
| Human Swiss link | |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthetic Peptide |
| Specificity | |
| Formulation | |
| Clonality | Monoclonal |
| Dilution | IHC 1:100-200 |
| Purification | |
| Concentration | 1mg/mL |
| Storage stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Molecular Weight (Da) | |
| Observed band (KD) | 65kDa |
| Background | NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection. |
| Function | |
| Subcellular location | Cytoplasm, Nucleus |
| Expression |
Additional Images
Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using Acetyl NF kB P65(K314/K315) （EM1377）Mouse mAb diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Human Lung Carcinoma Tissue using Acetyl NF kB P65(K314/K315) （EM1377）Mouse mAb diluted at 1:200.
: EM1377-100
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