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Antibody Product Overview
| ELK.No | ES1676 |
| Product name | APC5 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | ANAPC5; APC5; Anaphase-promoting complex subunit 5; APC5; Cyclosome subunit 5 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 51433 |
| Human Swiss-Prot | Q9UJX4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | APC5 |
| Fields | >>Cell cycle;>>Oocyte meiosis;>>Ubiquitin mediated proteolysis;>>IL-17 signaling pathway;>>Progesterone-mediated oocyte maturation;>>Human T-cell leukemia virus 1 infection |
| Gene name | ANAPC5 |
| Protein name | Anaphase-promoting complex subunit 5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q8BTZ4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ANAPC5. AA range:151-200 |
| Specificity | APC5 Polyclonal Antibody detects endogenous levels of APC5 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 85kD |
| Background | This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008], |
| Function | function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the APC5 family.,similarity:Contains 4 TPR repeats.,subunit:The APC/C is composed of at least 11 subunits., |
| Subcellular location | Nucleus . Cytoplasm, cytoskeleton, spindle . |
| Expression | Brain,Cerebellum,Cervix,Epithelium,Lung,Oesophagus,Periodontal liga |
Additional Images
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Western Blot analysis of various cells using APC5 Polyclonal Antibody
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Western blot analysis of the lysates from HeLa cells using ANAPC5 antibody.
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: AO-06-ES1676-100
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