Français
English
Antibody Product Overview
| ELK.No | ES1676 |
| Product name | APC5 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | ANAPC5; APC5; Anaphase-promoting complex subunit 5; APC5; Cyclosome subunit 5 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 51433 |
| Human Swiss-Prot | Q9UJX4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | APC5 |
| Fields | >>Cell cycle;>>Oocyte meiosis;>>Ubiquitin mediated proteolysis;>>IL-17 signaling pathway;>>Progesterone-mediated oocyte maturation;>>Human T-cell leukemia virus 1 infection |
| Gene name | ANAPC5 |
| Protein name | Anaphase-promoting complex subunit 5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q8BTZ4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ANAPC5. AA range:151-200 |
| Specificity | APC5 Polyclonal Antibody detects endogenous levels of APC5 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 85kD |
| Background | This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008], |
| Function | function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the APC5 family.,similarity:Contains 4 TPR repeats.,subunit:The APC/C is composed of at least 11 subunits., |
| Subcellular location | Nucleus . Cytoplasm, cytoskeleton, spindle . |
| Expression | Brain,Cerebellum,Cervix,Epithelium,Lung,Oesophagus,Periodontal liga |
Additional Images
No image
Western Blot analysis of various cells using APC5 Polyclonal Antibody
No image
Western blot analysis of the lysates from HeLa cells using ANAPC5 antibody.
No image
No image
: AO-06-ES1676-100
: 10 Produits
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package