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Antibody Product Overview
| ELK.No | ES3249 |
| Product name | PP2Cκ rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | PPM1K; PP2CM; Protein phosphatase 1K; mitochondrial; PP2C domain-containing protein phosphatase 1K; PP2C-like mitochondrial protein; PP2C-type mitochondrial phosphoprotein phosphatase; PTMP; Protein phosphatase 2C isoform kappa; PP2C-kappa |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 152926 |
| Human Swiss-Prot | Q8N3J5 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PP2Cκ |
| Fields | |
| Gene name | PPM1K |
| Protein name | Protein phosphatase 1K mitochondrial |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q8BXN7 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PPM1K. AA range:205-254 |
| Specificity | PP2Cκ Polyclonal Antibody detects endogenous levels of PP2Cκ protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 45kD |
| Background | This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012], |
| Function | catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,caution:Ref.9 has crystallized PPM1K in the presence of magnesium ions. However, PubMed:17336929 reported that no activity toward p-nitrophenylphosphate was seen in the absence of manganese ions and magnesium could not subsitute for manganese.,cofactor:Binds 1 magnesium or manganese ion per subunit.,function:Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.,similarity:Belongs to the PP2C family.,similarity:Contains 1 PP2C-like domain., |
| Subcellular location | Mitochondrion matrix . |
| Expression | Amygdala,Cerebellum,Lymph node,Pancreas,Testis, |
Additional Images
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Western Blot analysis of various cells using PP2Cκ Polyclonal Antibody
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Immunohistochemistry analysis of paraffin-embedded human pancreas tissue, using PPM1K Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from 293 cells, using PPM1K Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from HeLa cells using PPM1K antibody.
: AO-06-ES3249-100
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