Français
English
Antibody Product Overview
| ELK.No | ES8011 |
| Product name | GPR56 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IF;ELISA |
| Other name | GPR56; TM7LN4; TM7XN1; G-protein coupled receptor 56; Protein TM7XN1 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 9289 |
| Human Swiss-Prot | Q9Y653 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GPR56 |
| Fields | |
| Gene name | GPR56 |
| Protein name | G-protein coupled receptor 56 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q8K209 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GPR56. AA range:251-300 |
| Specificity | GPR56 Polyclonal Antibody detects endogenous levels of GPR56 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 78kD |
| Background | This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014], |
| Function | disease:Defects in GPR56 are the cause of bilateral frontoparietal polymicrogyria (BFPP) [MIM:606854]. BFPP is characterized by disorganized cortical lamination that is most severe in frontal cortex.,function:Could be involved in cell-cell interactions.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,tissue specificity:Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein .; [ADGRG1 N-terminal fragment]: Secreted .; [ADGRG1 C-terminal fragment]: Membrane raft . Interaction with its ligand COL3A1 leads to the release of ADGRG1 NT from the membrane and triggers the association of ADGRG1 CT with lipid rafts. . |
| Expression | Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells. Expression is down-regulated in different tumors from highly metastatic cells. |
Additional Images
No image
Western Blot analysis of NIH-3T3 cells using GPR56 Polyclonal Antibody diluted at 1:1000
No image
Immunofluorescence analysis of MCF7 cells, using GPR56 Antibody. The picture on the right is blocked with the synthesized peptide.
No image
Western blot analysis of lysates from K562 cells, using GPR56 Antibody. The lane on the right is blocked with the synthesized peptide.
No image
: AO-06-ES8011-100
: 10 Produits
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package